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Titel:

Nfkb 1 is dispensable for Myc-induced lymphomagenesis.

Dokumenttyp:
Journal Article
Autor(en):
Keller, U; Nilsson, JA; Maclean, KH; Old, JB; Cleveland, JL
Abstract:
Rel/NF-kappaB transcription factors are critical arbiters of immune responses, cell survival, and transformation, and are frequently deregulated in cancer. The p50 NF-kappaB 1 component of Rel/NF-kappaB DNA-binding dimers regulates genes involved in both cell cycle traverse and apoptosis. Nfkb 1 loss accelerates B cell growth and leads to increased B cell turnover in vivo, phenotypes akin to those manifested in B cells of Emu-Myc transgenic mice, a model of human Burkitt lymphoma. Interestingly,...     »
Zeitschriftentitel:
Oncogene
Jahr:
2005
Band / Volume:
24
Heft / Issue:
41
Seitenangaben Beitrag:
6231-40
Sprache:
eng
Volltext / DOI:
doi:10.1038/sj.onc.1208779
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/15940251
Print-ISSN:
0950-9232
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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