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Titel:

Enhanced microarray performance using low complexity representations of the transcriptome.

Dokumenttyp:
Evaluation Studies; Journal Article
Autor(en):
Rondeau, G; McClelland, M; Nguyen, T; Risques, R; Wang, Y; Judex, M; Cho, AH; Welsh, J
Abstract:
Low abundance mRNAs are more difficult to examine using microarrays than high abundance mRNAs due to the effect of concentration on hybridization kinetics and signal-to-noise ratios. This report describes the use of low complexity representations (LCRs) of mRNA as the targets for cDNA microarrays. Individual sequences in LCRs are more highly represented than in the mRNA populations from which they are derived, leading to favorable hybridization kinetics. LCR targets permit the measurement of abu...     »
Zeitschriftentitel:
Nucleic Acids Res
Jahr:
2005
Band / Volume:
33
Heft / Issue:
11
Seitenangaben Beitrag:
e100
Sprache:
eng
Volltext / DOI:
doi:10.1093/nar/gni095
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/15987785
Print-ISSN:
0305-1048
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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