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Title:

The major surface protein of Wolbachia endosymbionts in filarial nematodes elicits immune responses through TLR2 and TLR4.

Document type:
Journal Article
Author(s):
Brattig, NW; Bazzocchi, C; Kirschning, CJ; Reiling, N; Büttner, DW; Ceciliani, F; Geisinger, F; Hochrein, H; Ernst, M; Wagner, H; Bandi, C; Hoerauf, A
Abstract:
More than 150 million humans in tropical countries are infected by filarial nematodes which harbor intracellular bacterial endosymbionts of the genus Wolbachia (Rickettsiales). These bacteria have been implicated in adverse effects of drug treatment in filariasis. The present study provides evidence that purified major Wolbachia surface protein (rWSP) acts as an inducer of the innate immune system through TLR2 and TLR4: 1) recombinant, stringently purified rWSP elicited the release of TNF-alpha,...     »
Journal title abbreviation:
J Immunol
Year:
2004
Journal volume:
173
Journal issue:
1
Pages contribution:
437-45
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15210803
Print-ISSN:
0022-1767
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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