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Title:

Antagonistic antibody prevents toll-like receptor 2-driven lethal shock-like syndromes.

Document type:
Journal Article; Article
Author(s):
Meng, G; Rutz, M; Schiemann, M; Metzger, J; Grabiec, A; Schwandner, R; Luppa, PB; Ebel, F; Busch, DH; Bauer, S; Wagner, H; Kirschning, CJ
Abstract:
Hyperactivation of immune cells by bacterial products through toll-like receptors (TLRs) is thought of as a causative mechanism of septic shock pathology. Infections with Gram-negative or Gram-positive bacteria provide TLR2-specific agonists and are the major cause of severe sepsis. In order to intervene in TLR2-driven toxemia, we raised mAb's against the extracellular domain of TLR2. Surface plasmon resonance analysis showed direct and specific interaction of TLR2 and immunostimulatory lipopept...     »
Journal title abbreviation:
J Clin Invest
Year:
2004
Journal volume:
113
Journal issue:
10
Pages contribution:
1473-81
Language:
eng
Fulltext / DOI:
doi:10.1172/JCI200420762
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15146245
Print-ISSN:
0021-9738
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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