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Title:

Identification of a TLR4- and TRIF-dependent activation program of dendritic cells.

Document type:
Journal Article
Author(s):
Weighardt, H; Jusek, G; Mages, J; Lang, R; Hoebe, K; Beutler, B; Holzmann, B
Abstract:
Dendritic cell activation by Toll-like receptors (TLR) is crucial for the generation of protective immune responses. In addition to the common myeloid differentiation factor 88 (MyD88)-dependent signaling pathway, TLR4 engages the adaptor protein Toll/IL-1 receptor (TIR)-domain-containing adaptor inducing IFN-beta (TRIF), leading to interferon regulatory factor 3 (IRF-3) activation and type I interferon production. Using microarray expression profiling we now identify TRIF as a major regulator o...     »
Journal title abbreviation:
Eur J Immunol
Year:
2004
Journal volume:
34
Journal issue:
2
Pages contribution:
558-64
Language:
eng
Fulltext / DOI:
doi:10.1002/eji.200324714
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/14768061
Print-ISSN:
0014-2980
TUM Institution:
Chirurgische Klinik und Poliklinik; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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