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Titel:

Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity.

Dokumenttyp:
Journal Article
Autor(en):
Evans, PC; Ovaa, H; Hamon, M; Kilshaw, PJ; Hamm, S; Bauer, S; Ploegh, HL; Smith, TS
Abstract:
Ubiquitination regulates the stability and/or activity of numerous cellular proteins. The corollary is that de-ubiquitinating enzymes, which 'trim' polyubiquitin chains from specific substrate proteins, play key roles in controlling fundamental cellular activities. Ubiquitin is essential at several stages during the activation of NF-kappaB (nuclear factor kappaB), a central co-ordinator of inflammation and other immune processes. Ubiquitination is known to cause degradation of the inhibitory mol...     »
Zeitschriftentitel:
Biochem J
Jahr:
2004
Band / Volume:
378
Heft / Issue:
Pt 3
Seitenangaben Beitrag:
727-34
Sprache:
eng
Volltext / DOI:
doi:10.1042/BJ20031377
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/14748687
Print-ISSN:
0264-6021
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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