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Titel:

Adenovirus-mediated overexpression of tissue inhibitor of metalloproteinases-1 in the liver: efficient protection against T-cell lymphoma and colon carcinoma metastasis.

Dokumenttyp:
Journal Article; Article
Autor(en):
Elezkurtaj, S; Kopitz, C; Baker, AH; Perez-Cantó, A; Arlt, MJ; Khokha, R; Gansbacher, B; Anton, M; Brand, K; Kruger, A
Abstract:
BACKGROUND: Matrix metalloproteinases (MMPs) are critical for metastasis of tumor cells. Tissue inhibitor of metalloproteinases-1 (TIMP-1), a natural MMP inhibitor, was shown to reduce metastasis in different models. Here, we investigated whether increased TIMP-1 levels in the liver achieved by adenoviral gene transfer will effectively inhibit liver metastasis of two independent tumor cell lines. METHOD: TIMP-1 was transferred with adenoviral vectors into the livers of DBA/2 and Balb/c mice, whi...     »
Zeitschriftentitel:
J Gene Med
Jahr:
2004
Band / Volume:
6
Heft / Issue:
11
Seitenangaben Beitrag:
1228-37
Sprache:
eng
Volltext / DOI:
doi:10.1002/jgm.637
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/15390257
Print-ISSN:
1099-498X
TUM Einrichtung:
Institut für Experimentelle Onkologie und Therapieforschung
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