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Title:

Strategies to overcome resistance to targeted protein kinase inhibitors.

Document type:
Journal Article; Review
Author(s):
Daub, H; Specht, K; Ullrich, A
Abstract:
Selective inhibition of protein tyrosine kinases is gaining importance as an effective therapeutic approach for the treatment of a wide range of human cancers. However, as extensively documented for the BCR-ABL oncogene in imatinib-treated leukaemia patients, clinical resistance caused by mutations in the targeted oncogene has been observed. Here, we look at how structural and mechanistic insights from imatinib-insensitive Bcr-Abl have been exploited to identify second-generation drugs that over...     »
Journal title abbreviation:
Nat Rev Drug Discov
Year:
2004
Journal volume:
3
Journal issue:
12
Pages contribution:
1001-10
Language:
eng
Fulltext / DOI:
doi:10.1038/nrd1579
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15573099
Print-ISSN:
1474-1776
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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