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Titel:

Mismatch repair protein hMSH2 in primary drug resistance in in vitro human malignant gliomas.

Dokumenttyp:
Journal Article
Autor(en):
Rellecke, P; Kuchelmeister, K; Schachenmayr, W; Schlegel, J
Abstract:
OBJECT: The mismatch repair (MMR) system has previously been implicated in acquired chemoresistance in malignant gliomas in humans. Its impact on the primary chemoresistance in glioblastoma multiforme (GBM) has not been determined in detail, however. METHODS: The authors investigated the expression of both the MMR genes (hMSH2, hMLH1, hPMS1, hPMS2, and hMSH6) at the transcriptional level through reverse transcription-polymerase chain reaction and the hMSH2 protein through Western blot and immuno...     »
Zeitschriftentitel:
J Neurosurg
Jahr:
2004
Band / Volume:
101
Heft / Issue:
4
Seitenangaben Beitrag:
653-8
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/15481721
Print-ISSN:
0022-3085
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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