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Titel:

Serial induction of mutations by ethylnitrosourea in PC12 cells: a new model for a phenotypical characterization of the neurotoxic response to 6-hydroxydopamine.

Dokumenttyp:
Journal Article
Autor(en):
Schlegel, J; Neff, F; Piontek, G
Abstract:
Here we show that the serial generation of allelic mutations by treatment with the mutagen ethylnitrosourea (ENU) in PC12 cells provides a new model for the phenotypical dissection of biological properties. We tested this approach in the neurotoxic 6-OHDA model of Parkinson's disease in PC12 cells which has been widely used as an in vitro model for the investigation of the molecular pathogenesis of neuronal cell death and for novel treatment approaches. ENU treatment at doses of 0.2 and 0.3 mg/m...     »
Zeitschriftentitel:
J Neurosci Methods
Jahr:
2004
Band / Volume:
137
Heft / Issue:
2
Seitenangaben Beitrag:
215-20
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.jneumeth.2004.02.010
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/15262063
Print-ISSN:
0165-0270
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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