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Title:

Influence of iodide and iodolactones on thyroid apoptosis. Evidence that apoptosis induced by iodide is mediated by iodolactones in intact porcine thyroid follicles.

Document type:
Journal Article
Author(s):
Langer, R; Burzler, C; Bechtner, G; Gärtner, R
Abstract:
Iodine induced thyroid involution is caused by apoptosis rather than necrosis. This effect of iodide on apoptosis of thyroid epithelial cells may be not a direct one but mediated by iodinated derivatives i.e. of polyunsaturated fatty acids, especially of iodolactones, which have previously shown to inhibit thyroid cell proliferation. We studied the influence on apoptosis of iodide (2 microM and 20 microM) and iodolactone (0.05 microM and 0.5 microM), with and without TSH (1 mU/ml), using a well...     »
Journal title abbreviation:
Exp Clin Endocrinol Diabetes
Year:
2003
Journal volume:
111
Journal issue:
6
Pages contribution:
325-9
Language:
eng
Fulltext / DOI:
doi:10.1055/s-2003-42721
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/14520597
Print-ISSN:
0947-7349
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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