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Titel:

Sequestration of p27Kip1 protein by cyclin D1 in typical and blastic variants of mantle cell lymphoma (MCL): implications for pathogenesis.

Dokumenttyp:
Journal Article
Autor(en):
Quintanilla-Martinez, L; Davies-Hill, T; Fend, F; Calzada-Wack, J; Sorbara, L; Campo, E; Jaffe, ES; Raffeld, M
Abstract:
p27 is a cyclin-dependent kinase inhibitor that plays a critical role in regulating G(1)/S progression, and whose activity is, in part, regulated through interactions with D-type cyclins. Mantle cell lymphoma (MCL) is characterized by the t(11; 14) translocation resulting in deregulated cyclin D1. We previously showed that p27 expression in MCL, as assessed by immunohistochemistry (IHC), does not show the usual inverse relationship to proliferate seen in most other lymphomas that do not overexpr...     »
Zeitschriftentitel:
Blood
Jahr:
2003
Band / Volume:
101
Heft / Issue:
8
Seitenangaben Beitrag:
3181-7
Sprache:
eng
Volltext / DOI:
doi:10.1182/blood-2002-01-0263
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/12515730
Print-ISSN:
0006-4971
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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