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Title:

Molecular characterization of Patched-associated rhabdomyosarcoma.

Document type:
Journal Article
Author(s):
Kappler, R; Calzada-Wack, J; Schnitzbauer, U; Koleva, M; Herwig, A; Piontek, G; Graedler, F; Adamski, J; Heinzmann, U; Schlegel, J; Hemmerlein, B; Quintanilla-Martinez, L; Hahn, H
Abstract:
Mutations in the human homologue of Drosophila Patched1 (PTCH1) have been found in several common tumours including basal cell carcinoma, medulloblastoma, and rhabdomyosarcoma (RMS). Medulloblastoma and RMS are also present in the murine model for Ptch1 deficiency. Tumours in heterozygous Ptch1(neo67/+) mice consistently exhibit elevated transcript levels of the proto-oncogene Gli1, of Ptch1 itself, and of the insulin-like growth factor 2 (Igf2). The present study has investigated additional mol...     »
Journal title abbreviation:
J Pathol
Year:
2003
Journal volume:
200
Journal issue:
3
Pages contribution:
348-56
Language:
eng
Fulltext / DOI:
doi:10.1002/path.1361
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/12845631
Print-ISSN:
0022-3417
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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