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Title:

Pathogenesis of DNA repair-deficient cancers: a statistical meta-analysis of putative Real Common Target genes.

Document type:
Journal Article; Meta-Analysis
Author(s):
Woerner, SM; Benner, A; Sutter, C; Schiller, M; Yuan, YP; Keller, G; Bork, P; Doeberitz, MK; Gebert, JF
Abstract:
DNA mismatch repair deficiency is observed in about 15% of human colorectal, gastric, and endometrial tumors and in lower frequencies in a minority of other tumors thereby causing insertion/deletion mutations at short repetitive sequences, recognized as microsatellite instability (MSI). Evolution of tumors, including those with MSI, is a continuous process of mutation and selection favoring neoplastic growth. Mutations in microsatellite-bearing genes that promote tumor cell growth in general (Re...     »
Journal title abbreviation:
Oncogene
Year:
2003
Journal volume:
22
Journal issue:
15
Pages contribution:
2226-35
Language:
eng
Fulltext / DOI:
doi:10.1038/sj.onc.1206421
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/12700659
Print-ISSN:
0950-9232
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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