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Titel:

Influence of iodide and iodolactones on thyroid apoptosis. Evidence that apoptosis induced by iodide is mediated by iodolactones in intact porcine thyroid follicles.

Dokumenttyp:
Journal Article
Autor(en):
Langer, R; Burzler, C; Bechtner, G; Gärtner, R
Abstract:
Iodine induced thyroid involution is caused by apoptosis rather than necrosis. This effect of iodide on apoptosis of thyroid epithelial cells may be not a direct one but mediated by iodinated derivatives i.e. of polyunsaturated fatty acids, especially of iodolactones, which have previously shown to inhibit thyroid cell proliferation. We studied the influence on apoptosis of iodide (2 microM and 20 microM) and iodolactone (0.05 microM and 0.5 microM), with and without TSH (1 mU/ml), using a well...     »
Zeitschriftentitel:
Exp Clin Endocrinol Diabetes
Jahr:
2003
Band / Volume:
111
Heft / Issue:
6
Seitenangaben Beitrag:
325-9
Sprache:
eng
Volltext / DOI:
doi:10.1055/s-2003-42721
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/14520597
Print-ISSN:
0947-7349
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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