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Titel:

Locoregional alpha-radioimmunotherapy of intraperitoneal tumor cell dissemination using a tumor-specific monoclonal antibody.

Dokumenttyp:
Journal Article; Article
Autor(en):
Huber, R; Seidl, C; Schmid, E; Seidenschwang, S; Becker, KF; Schuhmacher, C; Apostolidis, C; Nikula, T; Kremmer, E; Schwaiger, M; Senekowitsch-Schmidtke, R
Abstract:
PURPOSE: The locoregional application of tumor-specific antibodies conjugated with highly cytotoxic alpha-emitters is a promising new strategy for therapy of i.p. tumor cell dissemination. Using this approach, an antibody specifically targeting diffuse-type gastric cancer cells was coupled to the high linear energy transfer alpha-emitter (213)Bi for treatment of i.p. tumor cell spread in a nude mouse model. EXPERIMENTAL DESIGN: Nude mice were inoculated with HSC45-M2 human gastric cancer cells e...     »
Zeitschriftentitel:
Clin Cancer Res
Jahr:
2003
Band / Volume:
9
Heft / Issue:
10 Pt 2
Seitenangaben Beitrag:
3922S-8S
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/14506190
Print-ISSN:
1078-0432
TUM Einrichtung:
Chirurgische Klinik und Poliklinik; Institut für Allgemeine Pathologie und Pathologische Anatomie; Klinik und Poliklinik für Nuklearmedizin
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