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Titel:

Pathogenesis of DNA repair-deficient cancers: a statistical meta-analysis of putative Real Common Target genes.

Dokumenttyp:
Journal Article; Meta-Analysis
Autor(en):
Woerner, SM; Benner, A; Sutter, C; Schiller, M; Yuan, YP; Keller, G; Bork, P; Doeberitz, MK; Gebert, JF
Abstract:
DNA mismatch repair deficiency is observed in about 15% of human colorectal, gastric, and endometrial tumors and in lower frequencies in a minority of other tumors thereby causing insertion/deletion mutations at short repetitive sequences, recognized as microsatellite instability (MSI). Evolution of tumors, including those with MSI, is a continuous process of mutation and selection favoring neoplastic growth. Mutations in microsatellite-bearing genes that promote tumor cell growth in general (Re...     »
Zeitschriftentitel:
Oncogene
Jahr:
2003
Band / Volume:
22
Heft / Issue:
15
Seitenangaben Beitrag:
2226-35
Sprache:
eng
Volltext / DOI:
doi:10.1038/sj.onc.1206421
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/12700659
Print-ISSN:
0950-9232
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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