Differential contribution of Toll-like receptors 4 and 2 to the cytokine response to Salmonella enterica serovar Typhimurium and Staphylococcus aureus in mice.

Titel:: Differential contribution of Toll-like receptors 4 and 2 to the cytokine response to Salmonella enterica serovar Typhimurium and Staphylococcus aureus in mice.
Dokumenttyp:: Journal Article
Autor(en):: Lembo, A; Kalis, C; Kirschning, CJ; Mitolo, V; Jirillo, E; Wagner, H; Galanos, C; Freudenberg, MA
Abstract:: The contribution of murine Toll-like receptors 2 and 4 (TLR2 and -4, respectively) to cytokine induction by heat-killed bacteria was analyzed in vitro and in vivo. Gram-negative bacteria induced cytokines primarily via TLR4; the contribution of TLR2 was only minor. Neither TLR4 nor, surprisingly, TLR2 was required in the MyD88-dependent response to Staphylococcus aureus.
Zeitschriftentitel:: Infect Immun
Jahr:: 2003
Band / Volume:: 71
Heft / Issue:: 10
Seitenangaben Beitrag:: 6058-62
Sprache:: eng
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/14500530
Print-ISSN:: 0019-9567
TUM Einrichtung:: Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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