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Document type:
Journal Article; Article
Author(s):
Alferink, J; Lieberam, I; Reindl, W; Behrens, A; Weiss, S; Hüser, N; Gerauer, K; Ross, R; Reske-Kunz, AB; Ahmad-Nejad, P; Wagner, H; Förster, I
Title:
Compartmentalized production of CCL17 in vivo: strong inducibility in peripheral dendritic cells contrasts selective absence from the spleen.
Abstract:
Dendritic cells (DCs)(*) fulfill an important regulatory function at the interface of the innate and adaptive immune system. The thymus and activation-regulated chemokine (TARC/CCL17) is produced by DCs and facilitates the attraction of activated T cells. Using a fluorescence-based in vivo reporter system, we show that CCL17 expression in mice is found in activated Langerhans cells and mature DCs located in various lymphoid and nonlymphoid organs, and is up-regulated after stimulation with Toll-...     »
Journal title abbreviation:
J Exp Med
Year:
2003
Journal volume:
197
Journal issue:
5
Pages contribution:
585-99
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/12615900
Print-ISSN:
0022-1007
TUM Institution:
Chirurgische Klinik und Poliklinik; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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