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Title:

Dendritic cell precursor populations of mouse blood: identification of the murine homologues of human blood plasmacytoid pre-DC2 and CD11c+ DC1 precursors.

Document type:
Journal Article
Author(s):
O'Keeffe, M; Hochrein, H; Vremec, D; Scott, B; Hertzog, P; Tatarczuch, L; Shortman, K
Abstract:
Immature and predendritic cells (pre-DCs) of human blood are the most readily accessible human DC sources available for study ex vivo. Murine homologues of human blood DCs have not been described. We report the isolation and characterization of 2 populations of precursor DCs in mouse blood. Mouse blood cells with the surface phenotype CD11c(lo)CD11b(-)CD45RA(hi) closely resemble human plasmacytoid cells (or pre-DC2) by morphology and function. On stimulation with oligonucleotides containing CpG...     »
Journal title abbreviation:
Blood
Year:
2003
Journal volume:
101
Journal issue:
4
Pages contribution:
1453-9
Language:
eng
Fulltext / DOI:
doi:10.1182/blood-2002-03-0974
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/12393665
Print-ISSN:
0006-4971
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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