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Title:

Viral escape and T-cell immunity during ganciclovir treatment of cytomegalovirus infection: case report of a pancreatico-renal transplant recipient.

Document type:
Case Reports; Journal Article
Author(s):
Benz, C; Holz, G; Michel, D; Awerkiew, S; Dries, V; Stippel, D; Goeser, T; Busch, DH
Abstract:
BACKGROUND: Pancreas-kidney transplant recipients are at high risk for cytomegalovirus (CMV) disease despite prophylactic ganciclovir therapy. Because the impact of antiviral therapy on anti-CMV immune reactions is unknown, CMV-specific T-cell subsets in primary and recurrent CMV infection were analyzed in a pancreas-kidney transplant case study. METHODS: Major histocompatibility complex class I tetramers were used to detect peripheral CMV pp65-specific CD8 T cells. Intracellular cytokine staini...     »
Journal title abbreviation:
Transplantation
Year:
2003
Journal volume:
75
Journal issue:
5
Pages contribution:
724-7
Language:
eng
Fulltext / DOI:
doi:10.1097/01.TP.0000052664.18029.E6
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/12640316
Print-ISSN:
0041-1337
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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