Benutzer: Gast  Login
Titel:

Apparently normal tumor necrosis factor receptor 1 signaling in the absence of the silencer of death domains.

Dokumenttyp:
Journal Article
Autor(en):
Endres, R; Häcker, G; Brosch, I; Pfeffer, K
Abstract:
The silencer of death domains (SODD) has been proposed to prevent constitutive signaling of tumor necrosis factor receptor 1 (TNFR1) in the absence of ligand. Besides TNFR1, death receptor 3 (DR3), Hsp70/Hsc70, and Bcl-2 have been characterized as binding partners of SODD. In order to investigate the in vivo role of SODD, we generated mice congenitally deficient in expression of the sodd gene. No spontaneous inflammatory infiltrations were observed in any organ of these mice. Consistent with thi...     »
Zeitschriftentitel:
Mol Cell Biol
Jahr:
2003
Band / Volume:
23
Heft / Issue:
18
Seitenangaben Beitrag:
6609-17
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/12944486
Print-ISSN:
0270-7306
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
 BibTeX