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Titel:

Inhibition of NF-kappaB activation in macrophages increases atherosclerosis in LDL receptor-deficient mice.

Dokumenttyp:
Journal Article
Autor(en):
Kanters, E; Pasparakis, M; Gijbels, MJ; Vergouwe, MN; Partouns-Hendriks, I; Fijneman, RJ; Clausen, BE; Förster, I; Kockx, MM; Rajewsky, K; Kraal, G; Hofker, MH; de Winther, MP
Abstract:
Atherosclerosis is now generally accepted as a chronic inflammatory condition. The transcription factor NF-kappaB is a key regulator of inflammation, immune responses, cell survival, and cell proliferation. To investigate the role of NF-kappaB activation in macrophages during atherogenesis, we used LDL receptor-deficient mice with a macrophage-restricted deletion of IkappaB kinase 2 (IKK2), which is essential for NF-kappaB activation by proinflammatory signals. These mice showed increased athero...     »
Zeitschriftentitel:
J Clin Invest
Jahr:
2003
Band / Volume:
112
Heft / Issue:
8
Seitenangaben Beitrag:
1176-85
Sprache:
eng
Volltext / DOI:
doi:10.1172/JCI200318580
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/14561702
Print-ISSN:
0021-9738
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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