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Titel:

Compartmentalized production of CCL17 in vivo: strong inducibility in peripheral dendritic cells contrasts selective absence from the spleen.

Dokumenttyp:
Journal Article; Article
Autor(en):
Alferink, J; Lieberam, I; Reindl, W; Behrens, A; Weiss, S; Hüser, N; Gerauer, K; Ross, R; Reske-Kunz, AB; Ahmad-Nejad, P; Wagner, H; Förster, I
Abstract:
Dendritic cells (DCs)(*) fulfill an important regulatory function at the interface of the innate and adaptive immune system. The thymus and activation-regulated chemokine (TARC/CCL17) is produced by DCs and facilitates the attraction of activated T cells. Using a fluorescence-based in vivo reporter system, we show that CCL17 expression in mice is found in activated Langerhans cells and mature DCs located in various lymphoid and nonlymphoid organs, and is up-regulated after stimulation with Toll-...     »
Zeitschriftentitel:
J Exp Med
Jahr:
2003
Band / Volume:
197
Heft / Issue:
5
Seitenangaben Beitrag:
585-99
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/12615900
Print-ISSN:
0022-1007
TUM Einrichtung:
Chirurgische Klinik und Poliklinik; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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