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Titel:

IL-4 regulates IL-12 p40 expression post-transcriptionally as well as via a promoter-based mechanism.

Dokumenttyp:
Journal Article
Autor(en):
Seegmüller, I; Häcker, H; Wagner, H
Abstract:
IL-12 and IL-4, respectively, dominate Th1 versus Th2 polarization. Additionally IL-4 can inhibit IL-12 p40 production in DC. Here we show that macrophages respond to bacterial CpG-DNA with IL-12 p40 production in an IL-4-sensitive manner. Analysis of the molecular mechanism of this inhibition shows that IL-4 acts by reducing the stability of IL-12 p40 mRNA as well as by affecting promoter activity. IL-4 did not affect early CpG-DNA-induced signal transduction. However, IL-4 reduced the activity...     »
Zeitschriftentitel:
Eur J Immunol
Jahr:
2003
Band / Volume:
33
Heft / Issue:
2
Seitenangaben Beitrag:
428-33
Sprache:
eng
Volltext / DOI:
doi:10.1002/immu.200310017
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/12645940
Print-ISSN:
0014-2980
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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