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Titel:

SOCS3 negatively regulates IL-6 signaling in vivo.

Dokumenttyp:
Journal Article
Autor(en):
Croker, BA; Krebs, DL; Zhang, JG; Wormald, S; Willson, TA; Stanley, EG; Robb, L; Greenhalgh, CJ; Förster, I; Clausen, BE; Nicola, NA; Metcalf, D; Hilton, DJ; Roberts, AW; Alexander, WS
Abstract:
Members of the suppressor of cytokine signaling (SOCS) family are potentially key physiological negative regulators of interleukin-6 (IL-6) signaling. To examine whether SOCS3 is involved in regulating this signaling, we have used conditional gene targeting to generate mice lacking Socs3 in the liver or in macrophages. We show that Socs3 deficiency results in prolonged activation of signal transducer and activator of transcription 1 (STAT1) and STAT3 after IL-6 stimulation but normal activation...     »
Zeitschriftentitel:
Nat Immunol
Jahr:
2003
Band / Volume:
4
Heft / Issue:
6
Seitenangaben Beitrag:
540-5
Sprache:
eng
Volltext / DOI:
doi:10.1038/ni931
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/12754505
Print-ISSN:
1529-2908
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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