Multivariate analysis of clinical prognostic factors in patients with glioblastoma multiforme treated with a combined modality approach.

Jeremic, B; Milicic, B; Grujicic, D; Dagovic, A; Aleksandrovic, J

doi:10.1007/s00432-003-0471-5

2003

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Titel:: Multivariate analysis of clinical prognostic factors in patients with glioblastoma multiforme treated with a combined modality approach.
Dokumenttyp:: Journal Article; Article
Autor(en):: Jeremic, B; Milicic, B; Grujicic, D; Dagovic, A; Aleksandrovic, J
Abstract:: We investigated the influence of various clinical prognostic factors in patients with glioblastoma multiforme (GBM) treated with a combined modality approach. A total of 175 patients with GBM was treated in four consecutive prospective phase II studies using surgery, hyperfractionated or accelerated hyperfractionated radiotherapy (RT) and either adjuvant or concurrent or pre-irradiation chemotherapy (CHT) between January 1988 and December 1993. The median survival time for all 175 patients was 14 months and 1-3-year survival (OS) rates were 57%, 34% and 24%, respectively. The median time to tumour progression was 12 months, and 1-3-year progression-free survival (PFS) rates were 43%, 11% and 7%, respectively. Survival analysis showed that of all investigated prognostic factors, only gender did not influence survival. Patients 55 years; patients with KPS 80-100 did better than those with KPS 50-70; patients with frontal tumours did better than those with tumours in other locations; patients with tumours up to 4 cm did better than those with larger tumours, as did patients with either subtotal or gross total tumour resection when compared to those undergoing biopsy only. Multivariate analysis showed that gender and tumour location did not independently influence survival. When PFS was used as the endpoint, only gender did not influence PFS, as confirmed by multivariate analysis.
Zeitschriftentitel:: J Cancer Res Clin Oncol
Jahr:: 2003
Band / Volume:: 129
Heft / Issue:: 8
Seitenangaben Beitrag:: 477-84
Sprache:: eng
Volltext / DOI:: doi:10.1007/s00432-003-0471-5
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/12884028
Print-ISSN:: 0171-5216
TUM Einrichtung:: Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Klinik und Poliklinik für RadioOnkologie und Strahlentherapie (Prof. Combs)2003