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Title:

Modified apoptotic molecule (BID) reduces hepatitis C virus infection in mice with chimeric human livers.

Document type:
Evaluation Studies; Journal Article; Validation Studies; Article
Author(s):
Hsu, EC; Hsi, B; Hirota-Tsuchihara, M; Ruland, J; Iorio, C; Sarangi, F; Diao, J; Migliaccio, G; Tyrrell, DL; Kneteman, N; Richardson, CD
Abstract:
Hepatitis C virus (HCV) encodes a polyprotein consisting of core, envelope (E1, E2, p7), and nonstructural polypeptides (NS2, NS3, NS4A, NS4B, NS5A, NS5B). The serine protease (NS3/NS4A), helicase (NS3), and polymerase (NS5B) constitute valid targets for antiviral therapy. We engineered BH3 interacting domain death agonist (BID), an apoptosis-inducing molecule, to contain a specific cleavage site recognized by the NS3/NS4A protease. Cleavage of the BID precursor molecule by the viral protease ac...     »
Journal title abbreviation:
Nat Biotechnol
Year:
2003
Journal volume:
21
Journal issue:
5
Pages contribution:
519-25
Language:
eng
Fulltext / DOI:
doi:10.1038/nbt817
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/12704395
Print-ISSN:
1087-0156
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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