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Title:

C1-INH and its effect on infarct size and ventricular function in an acute pig model of infarction, cardiopulmonary bypass, and reperfusion.

Document type:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Schreiber, C; Heimisch, W; Schad, H; Brkic, A; Badiu, C; Lange, R; Bauernschmitt, R
Abstract:
BACKGROUND: Recent studies suggest that complement inhibition reduces reperfusion injury. A clinical setting with local application of a C1 esterase inhibitor (C1-INH) has been modeled in an animal study in order to further investigate these findings. METHODS: In 21 pigs, the left anterior descending coronary artery (LAD) was occluded distally to the first diagonal branch for 2 hours (h), including 1 h of cardioplegic arrest during CPB. After release of the coronary snare, C1-INH or NaCl (contro...     »
Journal title abbreviation:
Thorac Cardiovasc Surg
Year:
2006
Journal volume:
54
Journal issue:
4
Pages contribution:
227-32
Language:
eng
Fulltext / DOI:
doi:10.1055/s-2006-923947
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/16755442
Print-ISSN:
0171-6425
TUM Institution:
Klinik für Herz- und Gefäßchirurgie (Prof. Lange)
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