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Title:

Forebrain CRF? modulates early-life stress-programmed cognitive deficits.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Wang, XD; Rammes, G; Kraev, I; Wolf, M; Liebl, C; Scharf, SH; Rice, CJ; Wurst, W; Holsboer, F; Deussing, JM; Baram, TZ; Stewart, MG; Müller, MB; Schmidt, MV
Abstract:
Childhood traumatic events hamper the development of the hippocampus and impair declarative memory in susceptible individuals. Persistent elevations of hippocampal corticotropin-releasing factor (CRF), acting through CRF receptor 1 (CRF?), in experimental models of early-life stress have suggested a role for this endogenous stress hormone in the resulting structural modifications and cognitive dysfunction. However, direct testing of this possibility has been difficult. In the current study, we s...     »
Journal title abbreviation:
J Neurosci
Year:
2011
Journal volume:
31
Journal issue:
38
Pages contribution:
13625-34
Language:
eng
Fulltext / DOI:
doi:10.1523/JNEUROSCI.2259-11.2011
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/21940453
Print-ISSN:
0270-6474
TUM Institution:
Klinik für Anästhesiologie (DHM)
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