Opioidergic changes in the pineal gland and hypothalamus in cluster headache: a ligand PET study.

Title:: Opioidergic changes in the pineal gland and hypothalamus in cluster headache: a ligand PET study.
Document type:: Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):: Sprenger, T; Willoch, F; Miederer, M; Schindler, F; Valet, M; Berthele, A; Spilker, ME; Förderreuther, S; Straube, A; Stangier, I; Wester, HJ; Tölle, TR
Abstract:: Using PET with the opioidergic ligand [11C]diprenorphine, the authors demonstrate decreased tracer binding in the pineal gland of cluster headache patients vs healthy volunteers. Opioid receptor availability in the hypothalamus and cingulate cortex depended on the duration of the headache disorder. Therefore, the pathophysiology of cluster headache may relate to opioidergic dysfunction in circuitries generating the biologic clock.
Journal title abbreviation:: Neurology
Year:: 2006
Journal volume:: 66
Journal issue:: 7
Pages contribution:: 1108-10
Language:: eng
Fulltext / DOI:: doi:10.1212/01.wnl.0000204225.15947.f8
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/16606930
Print-ISSN:: 0028-3878
TUM Institution:: Klinik und Poliklinik für Nuklearmedizin; Neurologische Klinik und Poliklinik
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