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Title:

Molecular analysis of light-chain switch and acute lymphoblastic leukemia transformation in two follicular lymphomas: Implications for lymphomagenesis.

Document type:
Journal Article
Author(s):
Kobrin, C; Cha, SC; Qin, H; Raffeld, M; Fend, F; Quintanilla-Martinez, L; Grove, S; Jaffe, ES; Kwak, LW
Abstract:
We observed novel transformations of follicular lymphoma (FL), first, a switch in immunoglobulin (Ig) light chain, and second, transformation of FL to acute lymphoblastic leukemia (ALL). Each set of tumors shared a common clonal origin, as demonstrated by expression of identical, unique CDR IIIH sequences, shared somatic mutations in JH, and identical bcl-2 translocation breakpoints of microdissected ALL cells. Molecular analysis of lambda V-gene expression demonstrated lambda-bearing cells in t...     »
Journal title abbreviation:
Leuk Lymphoma
Year:
2006
Journal volume:
47
Journal issue:
8
Pages contribution:
1523-34
Language:
eng
Fulltext / DOI:
doi:10.1080/10428190600612909
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/16966263
Print-ISSN:
1042-8194
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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