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Title:

Prevalence of the mismatch-repair-deficient phenotype in colonic adenomas arising in HNPCC patients: results of a 5-year follow-up study.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Müller, A; Beckmann, C; Westphal, G; Bocker Edmonston, T; Friedrichs, N; Dietmaier, W; Brasch, FE; Kloor, M; Poremba, C; Keller, G; Aust, DE; Fass, J; Büttner, R; Becker, H; Rüschoff, J
Abstract:
In hereditary nonpolyposis colorectal cancer (HNPCC) syndrome, more than 90% of the carcinomas show microsatellite instability (MSI) due to a loss of mismatch repair (MMR) function. Although adenomas are very common in HNPCC and demonstrate an accelerated adenoma-carcinoma sequence, data about the prevalence and development of MSI in these early neoplastic lesions are lacking. To determine whether MSI and loss of MMR-protein expression are already present in early stages of tumorigenesis and cou...     »
Journal title abbreviation:
Int J Colorectal Dis
Year:
2006
Journal volume:
21
Journal issue:
7
Pages contribution:
632-41
Language:
eng
Fulltext / DOI:
doi:10.1007/s00384-005-0073-6
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/16511680
Print-ISSN:
0179-1958
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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