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Titel:

Actin filament turnover drives leading edge growth during myelin sheath formation in the central nervous system.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Nawaz, Schanila; Sánchez, Paula; Schmitt, Sebastian; Snaidero, Nicolas; Mitkovski, Mi?o; Velte, Caroline; Brückner, Bastian R; Alexopoulos, Ioannis; Czopka, Tim; Jung, Sang Y; Rhee, Jeong S; Janshoff, Andreas; Witke, Walter; Schaap, Iwan A T; Lyons, David A; Simons, Mikael
Abstract:
During CNS development, oligodendrocytes wrap their plasma membrane around axons to generate multilamellar myelin sheaths. To drive growth at the leading edge of myelin at the interface with the axon, mechanical forces are necessary, but the underlying mechanisms are not known. Using an interdisciplinary approach that combines morphological, genetic, and biophysical analyses, we identified a key role for actin filament network turnover in myelin growth. At the onset of myelin biogenesis, F-actin...     »
Zeitschriftentitel:
Dev Cell
Jahr:
2015
Band / Volume:
34
Heft / Issue:
2
Seitenangaben Beitrag:
139-51
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.devcel.2015.05.013
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/26166299
Print-ISSN:
1534-5807
TUM Einrichtung:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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