Optoacoustic imaging enabled biodistribution study of cationic polymeric biodegradable nanoparticles.

Egusquiaguirre, Susana P; Beziere, Nicolas; Pedraz, José Luís; Hernández, Rosa M; Ntziachristos, Vasilis; Igartua, Manuela

doi:10.1002/cmmi.1644

Benutzer: Gast

2015

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Titel:: Optoacoustic imaging enabled biodistribution study of cationic polymeric biodegradable nanoparticles.
Dokumenttyp:: Journal Article; Article
Autor(en):: Egusquiaguirre, Susana P; Beziere, Nicolas; Pedraz, José Luís; Hernández, Rosa M; Ntziachristos, Vasilis; Igartua, Manuela
Abstract:: Nanosized contrast agents for molecular imaging have attracted widespread interest for diagnostic applications with high resolution in medicine. However, many solid nanoparticles exhibit a great potential to induce toxicity, hindering their use for clinical applications. On the other hand, near-infrared (NIR) dyes have also been used for extensive biological applications, but show some limitations due to their poor aqueous stability, tendency to aggregation and rapid elimination from the body. An alternative proposed in this work to overcome these limitations is the use of NIR dye-loaded nanoparticles. Here we introduce nanoparticles constructed with poly(D,L-lactide-co-glycolic acid) (PLGA), a biodegradable and biocompatible polymer widely used for biomedical applications, attached to the polycation polyethyleneimine (PEI) to obtain positively charged nanoparticles. The in vivo biodistribution of the cationic PEI-PLGA nanoparticles was investigated after administration through three different routes (intravenous, intraperitoneal and subcutaneous) using multispectral optoacoustic tomography (MSOT). The prepared nanoparticles exhibited good colloidal stability and adequate optical properties for optoacoustic imaging. The in vivo biodistribution assays indicated a strong accumulation of the particles in the liver and spleen, and retention in these organs for at least 24 h. Therefore, these nanoparticles could find promising applications in MSOT due to a sharp and characteristic optoacoustic spectrum and high optoacoustic signal generation, and become a promising building block for theranostic strategies. Copyright © 2015 John Wiley & Sons, Ltd.
Zeitschriftentitel:: Contrast Media Mol Imaging
Jahr:: 2015
Band / Volume:: 10
Heft / Issue:: 6
Seitenangaben Beitrag:: 421-7
Sprache:: eng
Volltext / DOI:: doi:10.1002/cmmi.1644
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/26018588
Print-ISSN:: 1555-4309
TUM Einrichtung:: Lehrstuhl für Biologische Bildgebung - Zusammenarbeit mit dem Helmholtz-Zentrum München (Prof. Ntziachristos)
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Preclinical Medicine Weitere Lehrstühle und Professuren Preclinical Medicine Lehrstuhl für Biologische Bildgebung - Zusammenarbeit mit dem Helmholtz-Zentrum München (Prof. Ntziachristos)2015