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Title:

Quantitative detection of drug dose and spatial distribution in the lung revealed by Cryoslicing Imaging.

Document type:
Journal Article; Article
Author(s):
Barapatre, Nirav; Symvoulidis, Panagiotis; Möller, Winfried; Prade, Friedrich; Deliolanis, Nikolaos C; Hertel, Sebastian; Winter, Gerhard; Yildirim, Ali Ö; Stoeger, Tobias; Eickelberg, Oliver; Ntziachristos, Vasilis; Schmid, Otmar
Abstract:
Administration of drugs via inhalation is an attractive route for pulmonary and systemic drug delivery. The therapeutic outcome of inhalation therapy depends not only on the dose of the lung-delivered drug, but also on its bioactivity and regional distribution. Fluorescence imaging has the potential to monitor these aspects already during preclinical development of inhaled drugs, but quantitative methods of analysis are lacking. In this proof-of-concept study, we demonstrate that Cryoslicing Ima...     »
Journal title abbreviation:
J Pharm Biomed Anal
Year:
2015
Journal volume:
102
Pages contribution:
129-36
Language:
eng
Fulltext / DOI:
doi:10.1016/j.jpba.2014.09.001
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25262414
Print-ISSN:
0731-7085
TUM Institution:
Lehrstuhl für Biologische Bildgebung - Zusammenarbeit mit dem Helmholtz-Zentrum München (Prof. Ntziachristos)
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