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Titel:

Quantitative detection of drug dose and spatial distribution in the lung revealed by Cryoslicing Imaging.

Dokumenttyp:
Journal Article; Article
Autor(en):
Barapatre, Nirav; Symvoulidis, Panagiotis; Möller, Winfried; Prade, Friedrich; Deliolanis, Nikolaos C; Hertel, Sebastian; Winter, Gerhard; Yildirim, Ali Ö; Stoeger, Tobias; Eickelberg, Oliver; Ntziachristos, Vasilis; Schmid, Otmar
Abstract:
Administration of drugs via inhalation is an attractive route for pulmonary and systemic drug delivery. The therapeutic outcome of inhalation therapy depends not only on the dose of the lung-delivered drug, but also on its bioactivity and regional distribution. Fluorescence imaging has the potential to monitor these aspects already during preclinical development of inhaled drugs, but quantitative methods of analysis are lacking. In this proof-of-concept study, we demonstrate that Cryoslicing Ima...     »
Zeitschriftentitel:
J Pharm Biomed Anal
Jahr:
2015
Band / Volume:
102
Seitenangaben Beitrag:
129-36
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.jpba.2014.09.001
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25262414
Print-ISSN:
0731-7085
TUM Einrichtung:
Lehrstuhl für Biologische Bildgebung - Zusammenarbeit mit dem Helmholtz-Zentrum München (Prof. Ntziachristos)
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