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Document type:
Journal Article; Research Support, Non-U.S. Gov't; Review; Review 
Author(s):
Simons, Mikael; Misgeld, Thomas; Kerschensteiner, Martin 
Title:
A unified cell biological perspective on axon-myelin injury. 
Abstract:
Demyelination and axon loss are pathological hallmarks of the neuroinflammatory disorder multiple sclerosis (MS). Although we have an increasingly detailed understanding of how immune cells can damage axons and myelin individually, we lack a unified view of how the axon-myelin unit as a whole is affected by immune-mediated attack. In this review, we propose that as a result of the tight cell biological interconnection of axons and myelin, damage to either can spread, which might convert a local...    »
 
Journal title abbreviation:
J Cell Biol 
Year:
2014 
Journal volume:
206 
Journal issue:
Pages contribution:
335-45 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
0021-9525 
TUM Institution:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)