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- Document type:
- Journal Article; Research Support, Non-U.S. Gov't; Article
- Author(s):
- Wang, Kai; Milkie, Daniel E; Saxena, Ankur; Engerer, Peter; Misgeld, Thomas; Bronner, Marianne E; Mumm, Jeff; Betzig, Eric
- Title:
- Rapid adaptive optical recovery of optimal resolution over large volumes.
- Abstract:
- Using a descanned, laser-induced guide star and direct wavefront sensing, we demonstrate adaptive correction of complex optical aberrations at high numerical aperture (NA) and a 14-ms update rate. This correction permits us to compensate for the rapid spatial variation in aberration often encountered in biological specimens and to recover diffraction-limited imaging over large volumes (>240 mm per side). We applied this to image fine neuronal processes and subcellular dynamics within the zebrafi... »
- Journal title abbreviation:
- Nat Methods
- Year:
- 2014
- Journal volume:
- 11
- Journal issue:
- 6
- Pages contribution:
- 625-8
- Language:
- eng
- Fulltext / DOI:
- doi:10.1038/nmeth.2925
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/24727653
- Print-ISSN:
- 1548-7091
- TUM Institution:
- Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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