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Titel:

CNS axons globally increase axonal transport after peripheral conditioning.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Mar, Fernando M; Simões, Anabel R; Leite, Sérgio; Morgado, Marlene M; Santos, Telma E; Rodrigo, Inês S; Teixeira, Carla A; Misgeld, Thomas; Sousa, Mónica M
Abstract:
Despite the inability of CNS axons to regenerate, an increased regenerative capacity can be elicited following conditioning lesion to the peripheral branch of dorsal root ganglia neurons (DRGs). By in vivo radiolabeling of rat DRGs, coupled to mass spectrometry and kinesin immunoprecipitation of spinal cord extracts, we determined that the anterograde transport of cytoskeleton components, metabolic enzymes and axonal regeneration enhancers, was increased in the central branch of DRGs following a...     »
Zeitschriftentitel:
J Neurosci
Jahr:
2014
Band / Volume:
34
Heft / Issue:
17
Seitenangaben Beitrag:
5965-70
Sprache:
eng
Volltext / DOI:
doi:10.1523/JNEUROSCI.4680-13.2014
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/24760855
Print-ISSN:
0270-6474
TUM Einrichtung:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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