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Title:

A unified cell biological perspective on axon-myelin injury.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Review; Review
Author(s):
Simons, Mikael; Misgeld, Thomas; Kerschensteiner, Martin
Abstract:
Demyelination and axon loss are pathological hallmarks of the neuroinflammatory disorder multiple sclerosis (MS). Although we have an increasingly detailed understanding of how immune cells can damage axons and myelin individually, we lack a unified view of how the axon-myelin unit as a whole is affected by immune-mediated attack. In this review, we propose that as a result of the tight cell biological interconnection of axons and myelin, damage to either can spread, which might convert a local...     »
Journal title abbreviation:
J Cell Biol
Year:
2014
Journal volume:
206
Journal issue:
3
Pages contribution:
335-45
Language:
eng
Fulltext / DOI:
doi:10.1083/jcb.201404154
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25092654
Print-ISSN:
0021-9525
TUM Institution:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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