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Title:

CNS axons globally increase axonal transport after peripheral conditioning.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Mar, Fernando M; Simões, Anabel R; Leite, Sérgio; Morgado, Marlene M; Santos, Telma E; Rodrigo, Inês S; Teixeira, Carla A; Misgeld, Thomas; Sousa, Mónica M
Abstract:
Despite the inability of CNS axons to regenerate, an increased regenerative capacity can be elicited following conditioning lesion to the peripheral branch of dorsal root ganglia neurons (DRGs). By in vivo radiolabeling of rat DRGs, coupled to mass spectrometry and kinesin immunoprecipitation of spinal cord extracts, we determined that the anterograde transport of cytoskeleton components, metabolic enzymes and axonal regeneration enhancers, was increased in the central branch of DRGs following a...     »
Journal title abbreviation:
J Neurosci
Year:
2014
Journal volume:
34
Journal issue:
17
Pages contribution:
5965-70
Language:
eng
Fulltext / DOI:
doi:10.1523/JNEUROSCI.4680-13.2014
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24760855
Print-ISSN:
0270-6474
TUM Institution:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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