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Title:

Multiparametric optical analysis of mitochondrial redox signals during neuronal physiology and pathology in vivo.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Article
Author(s):
Breckwoldt, Michael O; Pfister, Franz M J; Bradley, Peter M; Marinkovi?, Petar; Williams, Philip R; Brill, Monika S; Plomer, Barbara; Schmalz, Anja; St Clair, Daret K; Naumann, Ronald; Griesbeck, Oliver; Schwarzländer, Markus; Godinho, Leanne; Bareyre, Florence M; Dick, Tobias P; Kerschensteiner, Martin; Misgeld, Thomas
Abstract:
Mitochondrial redox signals have a central role in neuronal physiology and disease. Here we describe a new optical approach to measure fast redox signals with single-organelle resolution in living mice that express genetically encoded redox biosensors in their neuronal mitochondria. Moreover, we demonstrate how parallel measurements with several biosensors can integrate these redox signals into a comprehensive characterization of mitochondrial function. This approach revealed that axonal mitocho...     »
Journal title abbreviation:
Nat Med
Year:
2014
Journal volume:
20
Journal issue:
5
Pages contribution:
555-60
Language:
eng
Fulltext / DOI:
doi:10.1038/nm.3520
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24747747
Print-ISSN:
1078-8956
TUM Institution:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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