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Titel:

A unified cell biological perspective on axon-myelin injury.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Review; Review
Autor(en):
Simons, Mikael; Misgeld, Thomas; Kerschensteiner, Martin
Abstract:
Demyelination and axon loss are pathological hallmarks of the neuroinflammatory disorder multiple sclerosis (MS). Although we have an increasingly detailed understanding of how immune cells can damage axons and myelin individually, we lack a unified view of how the axon-myelin unit as a whole is affected by immune-mediated attack. In this review, we propose that as a result of the tight cell biological interconnection of axons and myelin, damage to either can spread, which might convert a local...     »
Zeitschriftentitel:
J Cell Biol
Jahr:
2014
Band / Volume:
206
Heft / Issue:
3
Seitenangaben Beitrag:
335-45
Sprache:
eng
Volltext / DOI:
doi:10.1083/jcb.201404154
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25092654
Print-ISSN:
0021-9525
TUM Einrichtung:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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