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Titel:

Rapid adaptive optical recovery of optimal resolution over large volumes.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Wang, Kai; Milkie, Daniel E; Saxena, Ankur; Engerer, Peter; Misgeld, Thomas; Bronner, Marianne E; Mumm, Jeff; Betzig, Eric
Abstract:
Using a descanned, laser-induced guide star and direct wavefront sensing, we demonstrate adaptive correction of complex optical aberrations at high numerical aperture (NA) and a 14-ms update rate. This correction permits us to compensate for the rapid spatial variation in aberration often encountered in biological specimens and to recover diffraction-limited imaging over large volumes (>240 mm per side). We applied this to image fine neuronal processes and subcellular dynamics within the zebrafi...     »
Zeitschriftentitel:
Nat Methods
Jahr:
2014
Band / Volume:
11
Heft / Issue:
6
Seitenangaben Beitrag:
625-8
Sprache:
eng
Volltext / DOI:
doi:10.1038/nmeth.2925
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/24727653
Print-ISSN:
1548-7091
TUM Einrichtung:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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