The Extracellular Matrix Metalloproteinase Inducer (EMMPRIN, CD147) - a potential novel target in atherothrombosis prevention?

Title:: The Extracellular Matrix Metalloproteinase Inducer (EMMPRIN, CD147) - a potential novel target in atherothrombosis prevention?
Document type:: Journal Article; Review
Author(s):: Joghetaei, Nader; Stein, Andreas; Byrne, Robert A; Schulz, Christian; King, Lamin; May, Andreas E; Schmidt, Roland
Abstract:: The immunoglobulin superfamily member EMMPRIN (CD147) plays an important role in a number of organ systems, including the cardiovascular system. Here we review the contemporary understanding of EMMPRIN and EMMPRIN-associated sequelae in the course of atherosclerosis. A significant body of data documents the pivotal role of EMMPRIN in the complex processes of atherogenesis, atheroprogression, and acute atherosclerothrombosis, a role that goes beyond that of a mere marker of inflammation.
Journal title abbreviation:: Thromb Res
Year:: 2013
Journal volume:: 131
Journal issue:: 6
Pages contribution:: 474-80
Language:: eng
Fulltext / DOI:: doi:10.1016/j.thromres.2013.04.017
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/23669100
Print-ISSN:: 0049-3848
TUM Institution:: Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (Prof. Schunkert)
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