Benutzer: Gast  Login
Mehr Felder
Einfache Suche
Titel:

Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Autor(en):
Soler Artigas, Maria; Wain, Louise V; Miller, Suzanne; Kheirallah, Abdul Kader; Huffman, Jennifer E; Ntalla, Ioanna; Shrine, Nick; Obeidat, Ma'en; Trochet, Holly; McArdle, Wendy L; Alves, Alexessander Couto; Hui, Jennie; Zhao, Jing Hua; Joshi, Peter K; Teumer, Alexander; Albrecht, Eva; Imboden, Medea; Rawal, Rajesh; Lopez, Lorna M; Marten, Jonathan; Enroth, Stefan; Surakka, Ida; Polasek, Ozren; Lyytikäinen, Leo-Pekka; Granell, Raquel; Hysi, Pirro G; Flexeder, Claudia; Mahajan, Anubha; Beilby, Jo...     »
Abstract:
Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P<5 × 10(-8)) in or near ENSA, RNU5F-1, KCNS3, AK097794, ASTN2, LHX3, CCDC91, TBX3, TRIP11, RIN3, TEKT5, LTBP4, MN1 and AP1S2, and two novel signals at known loci NPNT and GPR126, providing a basis for new understanding of the genetic determinants of these traits and pulmonary diseases in which they are altered.
Zeitschriftentitel:
Nat Commun
Jahr:
2015
Band / Volume:
6
Seitenangaben Beitrag:
8658
Sprache:
eng
Volltext / DOI:
doi:10.1038/ncomms9658
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/26635082
Print-ISSN:
2041-1723
TUM Einrichtung:
Lehrstuhl für Allgemeinmedizin (Prof. Schneider) (keine SAP-Zuordnung!)
 BibTeX