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Titel:

SOX2 promotes a cancer stem cell-like phenotype and local spreading in oral squamous cell carcinoma.

Dokumenttyp:
Journal Article
Autor(en):
Sacco, Alessandro; Battaglia, Anna Martina; Santamaria, Gianluca; Buffone, Caterina; Barone, Selene; Procopio, Anna; Lavecchia, Anna Maria; Aversa, Ilenia; Giorgio, Emanuele; Petriaggi, Lavinia; Cristofaro, Maria Giulia; Biamonte, Flavia; Giudice, Amerigo
Abstract:
Emerging evidence shows that oral squamous cell carcinoma (OSCC) invasiveness can be attributed to a small subpopulation of cancer stem cells (CSCs) in the bulk of the tumor. However, the presence of CSCs in the OSCC close resection margins is still poorly unexplored. Here, we found that BMI1, CD44, SOX2, OCT4, UBE2C, CXCR4 CSCs marker genes are significantly upregulated, while IGF1-R, KLF4, ALDH1A1, CD133, FAM3C are downregulated in the tumor core vs healthy mucosa of 24 patients with OSCC. Amo...     »
Zeitschriftentitel:
PLoS ONE
Jahr:
2023
Band / Volume:
18
Heft / Issue:
12
Volltext / DOI:
doi:10.1371/journal.pone.0293475
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/38096163
Print-ISSN:
1932-6203
TUM Einrichtung:
Professur für Regenerative Medizin bei Kardiovaskulären Erkrankungen (Prof. Moretti)
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