Benutzer: Gast  Login
Titel:

Interferon-? and Tumor Necrosis Factor-? Produced by T Cells Reduce the HBV Persistence Form, cccDNA, Without Cytolysis.

Dokumenttyp:
Journal Article; Article
Autor(en):
Xia, Yuchen; Stadler, Daniela; Lucifora, Julie; Reisinger, Florian; Webb, Dennis; Hösel, Marianna; Michler, Thomas; Wisskirchen, Karin; Cheng, Xiaoming; Zhang, Ke; Chou, Wen-Min; Wettengel, Jochen M; Malo, Antje; Bohne, Felix; Hoffmann, Dieter; Eyer, Florian; Thimme, Robert; Falk, Christine S; Thasler, Wolfgang E; Heikenwälder, Mathias; Protzer, Ulrike
Abstract:
Viral clearance involves immune cell cytolysis of infected cells. However, studies of hepatitis B virus (HBV) infection in chimpanzees have indicated that cytokines released by T cells also can promote viral clearance via noncytolytic processes. We investigated the noncytolytic mechanisms by which T cells eliminate HBV from infected hepatocytes.We performed a cytokine enzyme-linked immunosorbent assay of serum samples from patients with acute and chronic hepatitis B. Liver biopsy specimens were...     »
Zeitschriftentitel:
Gastroenterology
Jahr:
2016
Band / Volume:
150
Heft / Issue:
1
Seitenangaben Beitrag:
194-205
Sprache:
eng
Volltext / DOI:
doi:10.1053/j.gastro.2015.09.026
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/26416327
Print-ISSN:
0016-5085
TUM Einrichtung:
2. Medizinische Klinik Toxikologische Abteilung (alt) (Prof. Zilker); Institut für Virologie
 BibTeX