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Titel:

L-type Calcium Channel Cav1.2 Is Required for Maintenance of Auditory Brainstem Nuclei.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Ebbers, Lena; Satheesh, Somisetty V; Janz, Katrin; Rüttiger, Lukas; Blosa, Maren; Hofmann, Franz; Morawski, Markus; Griesemer, Désirée; Knipper, Marlies; Friauf, Eckhard; Nothwang, Hans Gerd
Abstract:
Cav1.2 and Cav1.3 are the major L-type voltage-gated Ca(2+) channels in the CNS. Yet, their individual in vivo functions are largely unknown. Both channel subunits are expressed in the auditory brainstem, where Cav1.3 is essential for proper maturation. Here, we investigated the role of Cav1.2 by targeted deletion in the mouse embryonic auditory brainstem. Similar to Cav1.3, loss of Cav1.2 resulted in a significant decrease in the volume and cell number of auditory nuclei. Contrary to the deleti...     »
Zeitschriftentitel:
J Biol Chem
Jahr:
2015
Band / Volume:
290
Heft / Issue:
39
Seitenangaben Beitrag:
23692-710
Sprache:
eng
Volltext / DOI:
doi:10.1074/jbc.M115.672675
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/26242732
Print-ISSN:
0021-9258
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie
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